Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM019804)
DM Name	PT2385 M1

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	PT2385 M10	Multi-steps Reaction - Hydroxylation; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	PT2385 M10	Multi-steps Reaction - Hydroxylation; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	PT2385 M10	Multi-steps Reaction - Hydroxylation; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 2B15 (UGT2B15)	DME0049	PT2385 M10	Multi-steps Reaction - Hydroxylation; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 2B17 (UGT2B17)	DME0066	PT2385 M10	Multi-steps Reaction - Hydroxylation; Glucuronide conjugation	PT2385	[1]

Full List of Drug(s) That Produce This DM By Metabolism
PT2385		DR3296	Phase 2		Von hippel-lindau disease

References
1	Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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