Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM019803)
DM Name
PT2385 M10
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006
PT2385
Oxidation - Hydroxylation PT2385 [1]
Cytochrome P450 1A2 (CYP1A2) DME0003
PT2385
Oxidation - Hydroxylation PT2385 [1]
Cytochrome P450 2C9 (CYP2C9) DME0019
PT2385
Oxidation - Hydroxylation PT2385 [1]
Cytochrome P450 2D6 (CYP2D6) DME0009
PT2385
Oxidation - Hydroxylation PT2385 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001
PT2385
Oxidation - Hydroxylation PT2385 [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
PT2385 M1
Multi-steps Reaction - Hydroxylation; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041
PT2385 M1
Multi-steps Reaction - Hydroxylation; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042
PT2385 M1
Multi-steps Reaction - Hydroxylation; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049
PT2385 M1
Multi-steps Reaction - Hydroxylation; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066
PT2385 M1
Multi-steps Reaction - Hydroxylation; Glucuronide conjugation PT2385 [1]
Full List of Drug(s) That Produce This DM By Metabolism
PT2385 DR3296 Phase 2 Von hippel-lindau disease
References
1 Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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