Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM019953)
DM Name
Erlotinib M2
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006
Erlotinib M14
Oxidation - O-demethylation Erlotinib hydrochloride [1] , [2]
Cytochrome P450 1A2 (CYP1A2) DME0003
Erlotinib M14
Oxidation - O-demethylation Erlotinib hydrochloride [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
Erlotinib M14
Oxidation - O-demethylation Erlotinib hydrochloride [1] , [2]
Cytochrome P450 3A5 (CYP3A5) DME0012
Erlotinib M14
Oxidation - O-demethylation Erlotinib hydrochloride [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Erlotinib hydrochloride DR0603 Approved Lung cancer
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.

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