Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM006620)
DM Name
6-methoxyethinylestradiol-glucuronide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
6-methoxyethinylestradiol
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041
6-methoxyethinylestradiol
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042
6-methoxyethinylestradiol
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
6-methoxyethinylestradiol
Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Ethinylestradiol propanesulfonate DR0658 Phase 4 Prostate cancer
References
1 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.