| General Information of Drug Metabolite (DM) (ID: DM019524) |
| DM Name |
LN1G
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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UDP-glucuronosyltransferase 1A1 (UGT1A1)
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DME0004
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| Unclear - Unclear |
Losartan
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[1] |
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UDP-glucuronosyltransferase 1A3 (UGT1A3)
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DME0041
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| Unclear - Unclear |
Losartan
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[1] |
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UDP-glucuronosyltransferase 2B7 (UGT2B7)
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DME0040
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| Unclear - Unclear |
Losartan
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Losartan |
DR3391
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Phase 3 |
Hypertension |
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| References |
| 1 |
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.
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