Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR3455)
Drug Name
Favipiravir
Prodrug Info Favipiravir is the prodrug of RTP
Synonyms AIDS121660; Favipiravir (JAN/INN); 3-bromo-5-hydroxy-4-methyl-2,6-dinitro-benzoic Acid; T705
Indication Influenza virus infection [ICD11: 1E30-1E32] Approved [1]
Coronavirus Disease 2019 (COVID-19) [ICD11: ICD11: 1D6Y] Phase 3 [2]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 157.1 Topological Polar Surface Area 84.6
Heavy Atom Count 11 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Cross-matching ID
PubChem CID
492405
ChEBI ID
CHEBI:134722
CAS Number
259793-96-9
TTD Drug ID
D04AGG
Formula
C5H4FN3O2
Canonical SMILES
C1=C(N=C(C(=O)N1)C(=O)N)F
InChI
InChI=1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
InChIKey
ZCGNOVWYSGBHAU-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Favipiravir-ribofuranosyl-5'-monophosphate (favipiravir-RMP) DM016609
135398735
Unclear - Unclear 1 [3]
M2 (favipiravir glucuronide conjugate) DM017645 N. A. Conjugation - Glucuronidation 1 [4]
T705M1 DM016735
146675095
Oxidation - Hydroxylation 1 [5]
RAD DM015504
6442177
Unclear - Unclear 2 [3]
RDP DM015148
124970
Unclear - Unclear 2 [3]
T-705-R DM015428
5271821
Unclear - Unclear 2 [3]
Favipiravir DM015312
492405
Unclear - Unclear 3 [3]
RTP DM015137
122108
Unclear - Unclear 3 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR009110 Favipiravir Favipiravir-ribofuranosyl-5'-monophosphate (favipiravir-RMP) Unclear - Unclear HPRT1 [3]
MR009116 Favipiravir T705M1 Oxidation - Hydroxylation xdhAC ... [5]
MR009117 Favipiravir M2 (favipiravir glucuronide conjugate) Conjugation - Glucuronidation UGT1A1 [4]
MR009111 Favipiravir-ribofuranosyl-5'-monophosphate (favipiravir-RMP) RDP Unclear - Unclear Unclear [3]
MR009113 Lactam EB-10101 T-705-R Unclear - Unclear CDK2 [3]
MR009115 Lactam EB-10101 RAD Unclear - Unclear NMNAT1 [3]
MR009112 RDP RTP Unclear - Unclear CDK2 [3]
MR009114 T-705-R Favipiravir Unclear - Unclear Unclear [3]
⏷ Show the Full List of 8 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
nicotinic acid mononucleotide adenylyltransferase (NMNAT) DMEN275 Homo sapiens Not Available Not Available [3]
References
1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 ClinicalTrials.gov (NCT04336904) Clinical Study To Evaluate The Performance And Safety Of Favipiravir in COVID-19
3 Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods
4 DrugBank(Pharmacology-Metabolism):Favipiravir
5 Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials

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