Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1092)
DME Name Aldehyde oxidase (AOX), Clostridium sporogenes
Synonyms Aldehyde oxidase/xanthine dehydrogenase; Xanthine dehydrogenase molybdopterin-binding; NCTC534_00123; VT96_0232590; xdhAC
Gene Name xdhAC
UniProt ID
A0A1V9IQJ2_CLOSG
EC Number    EC: 1.17.1.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH/CH2 oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.17.1.4
Lineage    Species: Clostridium sporogenes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium sporogenes
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MYEFILNGRNVSVSEDMNLLEYLRDHEDLTSVKNGCAEGACGACMILLDGKAVRACINTT
AKVHGKDIKTVEGLTEFEKKVFTWAFSKAGAVQCGFCIPGMIISAKALLDKNLNPNKKEI
KTAIRGNVCRCTGYVKIIKAIEMAAEAFRDGKLILNEEYKGKIGENIPRIDARDKILGIG
KYVDDMKVEGMIYGSALRIKYPRALVKSIDISEALKHPDVETIITAKDIPGNRYIGHIIK
DWPAMIDVGEETRYVGDSVALVAAKNKKALKEILNLIKVEYEELEPISNPDMAMDEDAPK
IHPKGNVLTVEKVNRGDVDEAIANSKYVVSNHYSTPFTEHAFLELESALAMPDEDGVIIY
TGSQGIYDEQREISELLGLPKEKVRTISKYVGGGFGGKEDMSVQHHAALLAWIIKKPVKV
TLSRKESIKIHPKRHAMEMTITTACDEKGNLTAFKADIVADTGAYASLGGPVLQRACTHA
AGPYKCPNVKIKGTAVYTNNPPGGAFRGFGVTQSVFASECNLNLLAQKVGISPWEIRFKN
AVEPGDALPNGQIADKGTAIKETILAVKDIYENNKYVGIACCMKNSGVGVGLPDIGRCNL
VVIKGKVHIRTSAACIGQGLGTILIQIICETTDLLPEQIILDLPDTKFAPNSGTTTASRQ
TVFTGEATRIASLKLKDKLLTTSLEECEGEEFYGEYQGITDPINSDKKNPVSHVAYGYAT
QVVILNDDGKVEKVVAAHDVGKAINSTNVEGQIEGGIVMGLGYAFTEDYPLNKSIPTAKF
GTLGLFRATDIPEIQPIIIEKNTNDLAYGAKGIGEITTIPTAPAAQGAYYKFDGEFRKKL
PLKDTAYRRKK
Function This enzyme acts on a variety of purines and aldehydes, including hypoxanthine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Zonisamide
 Drug Info Approved Epilepsy ICD11: 8A60 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR010062 ABT-418 ABT-418 Metabolite M1 Oxidation - N'-oxidation ABT-418 [2], [3]
MR009116 Favipiravir T705M1 Oxidation - Hydroxylation Favipiravir [4]
MR013772 Methotrexate Sodium 7-hydroxymethotrexate Oxidation - Oxidation Methotrexate Sodium [5], [6]
MR010183 Savolitinib Savolitinib Metabolite M3 Unclear - Unclear Savolitinib [7]
MR010533 VX-509 VX-509 Metabolite M3 Oxidation - Hydroxylation VX-509 [8]
References
1 The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide. J Pharm Pharmacol. 1997 Mar;49(3):253-6.
2 The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans
3 In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation
4 Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials
5 Determination of methotrexate and its major metabolite, 7-hydroxymethotrexate, using capillary zone electrophoresis and laser-induced fluorescence detection
6 In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase
7 A Phase 1 Study to Evaluate Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Savolitinib in Healthy Male Volunteers
8 VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions

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