Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0791)
Drug Name
Griseofulvin
Synonyms
Gresfeed; Gricin; Grifulin; Grifulvin; Grifulvin V; Grisactin; Grisactin Ultra; Griscofulvin; Grisefuline; Griseo; Griseofulvin forte; Griseofulvin-forte; Griseofulvina; Griseofulvine; Griseofulvinum; Griseomix; Grisetin; Grisofulvin; Grisovin; Grizeofulvin; Grysio; Guservin; Lamoryl; Likuden; Murfulvin; Neo-Fulcin; Poncyl; Spirofulvin; Amudane; Biogrisin-FP; Curling factor; Delmofulvina; Fulcin; Fulcine; Fulvican grisactin; Fulvicin; Fulvicin-U/F; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin; griseofulvin; (+)-Griseofulvin; 126-07-8
Indication Dermatophytosis [ICD11: 1F28] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 352.8 Topological Polar Surface Area 71.1
Heavy Atom Count 24 Rotatable Bond Count 3
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
441140
PubChem SID
8911 ; 603057 ; 1240856 ; 3139652 ; 7847276 ; 7979462 ; 8149360 ; 10298748 ; 10321345 ; 11335329 ; 11341607 ; 11360568 ; 11361790 ; 11363710 ; 11366272 ; 11368834 ; 11371221 ; 11374592 ; 11376996 ; 11461540 ; 11483961 ; 11487192 ; 11488029 ; 11489977 ; 11492742 ; 11494630 ; 11537460 ; 14778634 ; 15026839 ; 17389865 ; 24869893 ; 24895099 ; 24895185 ; 26613001 ; 26680363 ; 26747301 ; 26747302 ; 29204198 ; 36885045 ; 46508437 ; 47216648 ; 47291003 ; 47736332 ; 47810614 ; 47959588 ; 48034972 ; 48110318 ; 48184863 ; 48259080 ; 48413831
ChEBI ID
ChEBI:27779
CAS Number
126-07-8
TTD Drug ID
D0C1SF
Formula
C17H17ClO6
Canonical SMILES
CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
InChI
1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
InChIKey
DDUHZTYCFQRHIY-RBHXEPJQSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
4-desmethylgriseofulvin DM004708
6452395
Unclear 1 [4]
6-desmethylgriseofulvin DM004709
9974417
Unclear 1 [4]
6-methyl-griseofulvin DM004707
131770040
Unclear 1 [5]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR005058 Griseofulvin 6-methyl-griseofulvin Unclear Unclear [5]
MR005059 Griseofulvin 4-desmethylgriseofulvin Unclear Unclear [4]
MR005060 Griseofulvin 6-desmethylgriseofulvin Unclear Unclear [4]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
Unclear metabolic mechanism (DME-unclear) DME1251 Bacteroides fragilis Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1254 Bacteroides thetaiotaomicron Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1256 Bacteroides sartorii Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1384 Bacteroides vulgatus Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1385 Bacteroides xylanisolvens Not Available Not Available [3]
Unclear metabolic mechanism (DME-unclear) DME1445 Parabacteroides distasonis Not Available Not Available [3]
⏷ Show the Full List of 8  DME(s)
References
1 Griseofulvin was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Kinetic mechanism of the activation of human plasminogen by streptokinase. Biochemistry. 1975 Oct 7;14(20):4459-65.
3 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
4 Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas
5 DrugBank(Pharmacology-Metabolism):Griseofulvin

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