General Information of DME (ID: DME1445)
DME Name Unclear metabolic mechanism (DME-unclear), Parabacteroides distasonis
Gene Name DME-unclear
Lineage    Species: Parabacteroides distasonis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides distasonis
Subspecies: Parabacteroides distasonis ATCC 8503
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        50 Drugs
Primaquine
Drug Info Approved Malaria ICD11: 1F40 [1]
Linagliptin
Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Mycophenolate mofetil
Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Febuxostat
Drug Info Approved Hyperuricaemia ICD11: 5C55 [1]
Deflazacort
Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Digitoxin
Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Finasteride
Drug Info Approved Prostatic hyperplasia ICD11: GA90 [1]
Naproxen
Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Nateglinide
Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Diltiazem hydrochloride
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Fluoxetine hydrochloride
Drug Info Approved Depression ICD11: 6A71 [1]
Oxaprozin
Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Phenytoin
Drug Info Approved Epilepsy ICD11: 8A60 [1]
Riluzole
Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Budesonide
Drug Info Approved Allergic rhinitis ICD11: CA08 [1]
Danazol
Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
Drug Info Approved Genital herpes ICD11: 1A94 [1]
Ritonavir
Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [1]
Sulfasalazine
Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Tolazamide
Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Vilazodone hydrochloride
Drug Info Approved Depression ICD11: 6A71 [1]
Clemastine fumarate
Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Griseofulvin
Drug Info Approved Dermatophytosis ICD11: 1F28 [1]
Loperamide hydrochloride
Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Losartan potassium
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Lovastatin
Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Pantoprazole sodium
Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Voriconazole
Drug Info Approved Candidiasis ICD11: 1F23 [1]
Bromocriptine mesylate
Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Carisoprodol
Drug Info Approved Depression ICD11: 6A71 [1]
Clopidogrel bisulfate
Drug Info Approved Acute coronary syndrome ICD11: BA4Z [1]
Entacapone
Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Mebendazole
Drug Info Approved Ascariasis ICD11: 1F62 [1]
Megestrol acetate
Drug Info Approved Breast cancer ICD11: 2C60 [1]
Melphalan
Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Quinapril
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tinidazole
Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Trandolapril
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Benazepril
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Fluphenazine decanoate
Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Olmesartan medoxomil
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Telmisartan
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Valsartan
Drug Info Approved Essential hypertension ICD11: BA00 [1]
Cetirizine
Drug Info Approved Allergy ICD11: 4A80 [1]
Dicyclomine
Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Diflorasone diacetate
Drug Info Approved Rosacea ICD11: ED90 [1]
Metaxalone
Drug Info Approved Myalgia ICD11: FB56 [1]
Methoxsalen
Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Ramelteon
Drug Info Approved Insomnia ICD11: 7A00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:        12 Drugs
Cyproterone acetate
Drug Info Phase 4 Polycystic ovary syndrome ICD11: 5A80 [1]
Famprofazone
Drug Info Phase 4 Anaesthesia ICD11: 8E22 [1]
Artemisinin
Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Idebenone
Drug Info Phase 4 Mitochondrial myopathy ICD11: 8C73 [1]
Gliclazide
Drug Info Phase 4 Diabetes mellitus ICD11: 5A10 [1]
L-phenylalanine
Drug Info Phase 4 Phenylketonuria ICD11: 5C50 [2]
Pericyazine
Drug Info Phase 4 Anxiety disorder ICD11: 6B00 [1]
Racecadotril
Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Nicergoline
Drug Info Phase 4 Acne vulgaris ICD11: ED80 [1]
Pidotimod
Drug Info Phase 4 Pulmonary tuberculosis ICD11: 1B10 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
OPC-12759
Drug Info Phase 3 Peptic ulcer ICD11: DA61 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Roxatidine
Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
TRP-01
Drug Info Phase 1 Depression ICD11: 6A71 [2]
BRN-0498823
Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
ML-236B
Drug Info Preclinical Hypertriglyceridaemia ICD11: 5C80 [1]
L-tyrosine
Drug Info Investigative Phenylketonuria ICD11: 5C50 [2]
Diacetamate
Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.

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