Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1636)
Drug Name
Triamterene
Synonyms
Taturil; Teriam; Teridin; Tri-Span; Triamizide; Triampur; Triamteren; Triamterenum; Triamteril; Triamteril complex; Triamthiazid; Tricilone; Trispan; Triteren; Triurene; Urocaudal; triamterene; 2,4,7-Triamino-6-phenylpteridine; 396-01-0; Ademin; Ademine; Dinazide; Diucelpin; Diurene; Diutensat; Diuteren; Dyberzide; Dyrenium; Dytenzide; Esiteren; Hidiurese; Hypertorr; Jatropur; Jenateren; Kalspare; Masuharmin; Noridil; Noridyl; Pterofen; Pterophene; Renezide; 6-Phenyl-2,4,7-pteridinetriamine; 6-phenylpteridine-2,4,7-triamine; Diren; Ditak; Dyren; Dytac
Indication Congestive heart failure [ICD11: BD10] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 253.26 Topological Polar Surface Area 130
Heavy Atom Count 19 Rotatable Bond Count 1
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Cross-matching ID
PubChem CID
5546
PubChem SID
118408 ; 602599 ; 855896 ; 933823 ; 5660597 ; 7847452 ; 8036221 ; 8149565 ; 8153414 ; 10321477 ; 11111878 ; 11111879 ; 11335608 ; 11360847 ; 11363402 ; 11365964 ; 11368526 ; 11372243 ; 11373970 ; 11376688 ; 11452214 ; 11461819 ; 11466062 ; 11467182 ; 11484612 ; 11485784 ; 11488754 ; 11491187 ; 11492181 ; 11494322 ; 14774401 ; 17389703 ; 17405750 ; 24277877 ; 26611958 ; 26679801 ; 26747035 ; 26751552 ; 29224587 ; 46507623 ; 47291080 ; 47588940 ; 47662218 ; 47662219 ; 47810690 ; 47885351 ; 47885352 ; 47959674 ; 48035047 ; 48334426
ChEBI ID
CHEBI:9671
CAS Number
396-01-0
TTD Drug ID
D00NKB
Formula
C12H11N7
Canonical SMILES
C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
InChI
1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
InChIKey
FNYLWPVRPXGIIP-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
4'-OH-triamterene DM002381
71046
Oxidation - Hydroxylation 1 [3] , [2]
4'-OH-triamterene sulfate metabolite DM002382
162951
Conjugation - Sulfation 2 [4] , [5]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR002451 Triamterene 4'-OH-triamterene Oxidation - Hydroxylation CYP1A2 [3], [2]
MR002450 4'-OH-triamterene 4'-OH-triamterene sulfate metabolite Conjugation - Sulfation SULT [4], [5]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Homo sapiens
CP1A2_HUMAN
1.14.14.1
[2]
References
1 Triamterene was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Rate-limiting biotransformation of triamterene is mediated by CYP1A2. Int J Clin Pharmacol Ther. 2005 Jul;43(7):327-34.
3 Extraction of structure-activity relationship information from high-throughput screening data Curr Med Chem. 2009;16(31):4049-57. doi: 10.2174/092986709789378189.
4 Pharmacokinetics of triamterene and its metabolite in man J Pharmacokinet Biopharm. 1982 Oct;10(5):507-23. doi: 10.1007/BF01059034.
5 Pharmacokinetics of triamterene Clin Exp Hypertens A. 1983;5(2):249-69. doi: 10.3109/10641968309048825.

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