Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000004)
Formula
ADH
SVG example
Oxidation
Reactant Abacavir Product 2269W93(Carboxylate)
Reactant Info Product Info
Metabolic Enzyme Alcohol dehydrogenase (ADH) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000006 Abacavir 1144U88 Unclear Abacavir [1]
MR000005 Abacavir 361W94(glucuronide) Conjugation - Glucuronidation Abacavir [2]
MR000003 Abacavir Abacavir monophosphate Other reaction - Phosphorylation Abacavir [3]
References
1 Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study Antimicrob Agents Chemother. 1999 Dec;43(12):2855-61. doi: 10.1128/AAC.43.12.2855.
2 Product characteristics of Triumeq
3 A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71.

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