Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000005)
Formula
SVG example
Glucuronidation
Reactant Abacavir Product 361W94(glucuronide)
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000006 Abacavir 1144U88 Unclear Abacavir [1]
MR000004 Abacavir 2269W93(Carboxylate) Oxidation - Oxidation Abacavir [2]
MR000003 Abacavir Abacavir monophosphate Other reaction - Phosphorylation Abacavir [3]
References
1 Pharmacokinetics of [(14)C]abacavir, a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study Antimicrob Agents Chemother. 1999 Dec;43(12):2855-61. doi: 10.1128/AAC.43.12.2855.
2 The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes Chem Biol Interact. 2002 Nov 10;142(1-2):135-54. doi: 10.1016/s0009-2797(02)00059-5.
3 A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71.

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