Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000023)
Formula
SVG example
Oxidation
Reactant Acalabrutinib Product ACP-5862
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000024 Acalabrutinib Acalabrutinib M2 metabolite Oxidation - Amide Hydrolysis; Oxidation Acalabrutinib [1]
MR000026 Acalabrutinib Acalabrutinib M25 metabolite Oxidation - Dehydration; Oxidation Acalabrutinib [1]
MR000027 Acalabrutinib Acalabrutinib M37 metabolite Oxidation - N-Dealkylation Acalabrutinib [1]
MR000025 Acalabrutinib ACP-5134 Other reaction - Hydration Acalabrutinib [1]
MR000022 Acalabrutinib ACP-5530 Conjugation - Glutathione Conjugation Acalabrutinib [1]
MR000028 Acalabrutinib ACP-5825 Oxidation - Hydroxylation Acalabrutinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000019 ACP-5862 Acalabrutinib M16 metabolite Reduction - Reduction Acalabrutinib [1]
MR000017 ACP-5862 Acalabrutinib M2 metabolite Oxidation - Amide Hydrolysis; Oxidation Acalabrutinib [1]
MR000018 ACP-5862 Acalabrutinib M3 metabolite Oxidation - N-Dealkylation; Oxidation Acalabrutinib [1]
References
1 Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans Drug Metab Dispos. 2019 Feb;47(2):145-154. doi: 10.1124/dmd.118.084459.

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