Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000063)
Formula Reactant Adefovir monophosphate Product Adefovir Diphosphate
Reactant Info Product Info
Metabolic Enzyme Nucleoside diphosphate kinase A (NME1) DME Info
Nucleoside diphosphate kinase B (NME2) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000062 Adefovir Adefovir monophosphate Other reaction - Phosphorylation Adefovir dipivoxil [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011017 Adefovir Dipivoxil Adefovir diphosphate Unclear - Unclear adefovir [2]
MR011015 Cyclic prodrug of Adefovir 3 Adefovir Diphosphate Unclear - Unclear adefovir [2]
MR002621 Adefovir Dipivoxil(ADV-DP)2 Adefovir Diphosphate(ADV-DP)4 Unclear ICN-2001-3 [2]
MR002620 Cyclic prodrug of Adefovir 3 Adefovir Diphosphate(ADV-DP)4 Unclear ICN-2001-3 [2]
References
1 Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells Biochem Pharmacol. 2004 Nov 1;68(9):1825-31. doi: 10.1016/j.bcp.2004.07.010.
2 Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.

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