Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002620)
Formula Reactant Cyclic prodrug of Adefovir 3 Product Adefovir Diphosphate(ADV-DP)4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011014 Adefovir Cyclic prodrug of Adefovir 3 Unclear - Unclear adefovir [1]
MR002619 Adefovir Cyclic prodrug of Adefovir 3 Unclear ICN-2001-3 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011017 Adefovir Dipivoxil Adefovir diphosphate Unclear - Unclear adefovir [1]
MR002621 Adefovir Dipivoxil(ADV-DP)2 Adefovir Diphosphate(ADV-DP)4 Unclear ICN-2001-3 [1]
MR000063 Adefovir monophosphate Adefovir Diphosphate Other reaction - Phosphorylation Adefovir dipivoxil [2]
References
1 Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.
2 Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells Biochem Pharmacol. 2004 Nov 1;68(9):1825-31. doi: 10.1016/j.bcp.2004.07.010.

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