Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000070)
Formula
AK1
SVG example
Phosphorylation
Reactant AMP Product ADP
Reactant Info Product Info
Metabolic Enzyme Adenylate kinase isoenzyme 1 (AK1) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000076 Adenosine AMP Other reaction - Phosphorylation Adenosine [1], [2]
MR004265 Adenine AMP Unclear Methylthioadenosine [3]
MR011012 Adenosine diphosphate Adenosine Phosphate Unclear - Unclear Adenosine triphosphate [4]
MR011569 IMP AMP Unclear - Unclear Acadesine [5]
MR000074 ATP AMP Other reaction - Dephosphorylation Adenosine [1], [2]
MR000072 ADP AMP Other reaction - Dephosphorylation Adenosine [1], [2]
MR004028 SAMP AMP Unclear Xanthine [6]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004266 AMP ATP Unclear Methylthioadenosine [3]
MR011570 AMP Adenosine Unclear - Unclear Acadesine [5]
MR011571 AMP AMPK Unclear - Unclear Acadesine [5]
MR000071 AMP Adenosine Other reaction - Dephosphorylation Adenosine [1], [2]
MR004029 AMP ATP Unclear Xanthine [6]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011011 Adenosine triphosphate Adenosine diphosphate Unclear - Unclear Adenosine triphosphate [4]
MR008287 DIADENOSINE TETRAPHOSPHATE ADP Hydrolysis - Hydrolysis DIADENOSINE TETRAPHOSPHATE [7]
MR000075 ATP ADP Other reaction - Dephosphorylation Adenosine [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011012 Adenosine diphosphate Adenosine Phosphate Unclear - Unclear Adenosine triphosphate [4]
MR000073 ADP ATP Other reaction - Phosphorylation Adenosine [1], [2]
MR000072 ADP AMP Other reaction - Dephosphorylation Adenosine [1], [2]
References
1 Adenosine Metabolism: Emerging Concepts for Cancer Therapy Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
2 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
3 Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies
4 ATP and its metabolite adenosine cooperatively upregulate the antigen-presenting molecules on dendritic cells leading to IFN- production by T cells
5 A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy
6 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism
7 Three diadenosine 5',5''-P1,P4-tetraphosphate hydrolytic enzymes from Physarum polycephalum with differential effects by calcium: a specific dinucleoside polyphosphate pyrophosphohydrolase, a nucleotide pyrophosphatase, and a phosphodiesterase

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