Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000073)
Formula
SVG example
Phosphorylation
Reactant ADP Product ATP
Reactant Info Product Info
Metabolic Enzyme Nucleoside diphosphate kinase A (NME1) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011011 Adenosine triphosphate Adenosine diphosphate Unclear - Unclear Adenosine triphosphate [1]
MR008287 DIADENOSINE TETRAPHOSPHATE ADP Hydrolysis - Hydrolysis DIADENOSINE TETRAPHOSPHATE [2]
MR000070 AMP ADP Other reaction - Phosphorylation Adenosine [3], [4]
MR000075 ATP ADP Other reaction - Dephosphorylation Adenosine [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011012 Adenosine diphosphate Adenosine Phosphate Unclear - Unclear Adenosine triphosphate [1]
MR000072 ADP AMP Other reaction - Dephosphorylation Adenosine [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000084 Adenosine-c-phosphate ATP Unclear Adenosine-c-phosphate [5]
MR000088 Adenylylsulfate ATP Unclear Adenylylsulfate [6]
MR004266 AMP ATP Unclear Methylthioadenosine [7]
MR004029 AMP ATP Unclear Xanthine [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000075 ATP ADP Other reaction - Dephosphorylation Adenosine [3], [4]
MR000074 ATP AMP Other reaction - Dephosphorylation Adenosine [3], [4]
References
1 ATP and its metabolite adenosine cooperatively upregulate the antigen-presenting molecules on dendritic cells leading to IFN- production by T cells
2 Three diadenosine 5',5''-P1,P4-tetraphosphate hydrolytic enzymes from Physarum polycephalum with differential effects by calcium: a specific dinucleoside polyphosphate pyrophosphohydrolase, a nucleotide pyrophosphatase, and a phosphodiesterase
3 Adenosine Metabolism: Emerging Concepts for Cancer Therapy Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
4 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
5 Transport and metabolism of N6- and C8-substituted analogs of adenosine 3',5'-cyclic monophosphate and adenosine 3'5'-cyclic phosphorothioate by the isolated perfused rat kidney Life Sci. 1983 Mar 28;32(13):1489-98. doi: 10.1016/0024-3205(83)90915-3.
6 Adenosine-5'-phosphosulfate--a multifaceted modulator of bifunctional 3'-phospho-adenosine-5'-phosphosulfate synthases and related enzymes FEBS J. 2013 Jul;280(13):3050-7. doi: 10.1111/febs.12252.
7 Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies
8 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism

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