Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000103)
Formula Reactant Agomelatine Product Agomelatine metabolite M5
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000104 Agomelatine Agomelatine metabolite M1 Oxidation - Monohydroxylation Agomelatine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000100 Agomelatine metabolite M5 Agomelatine metabolite M6 Oxidation - Monohydroxylation Agomelatine [1]
References
1 Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches Biochem Pharmacol. 2016 Jun 1;109:70-82. doi: 10.1016/j.bcp.2016.03.020.

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