Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000131)
Formula Reactant Aliskiren metabolite M4 Product Aliskiren metabolite M6
Reactant Info Product Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000133 Aliskiren Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
MR000129 Aliskiren metabolite M3 Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
MR000130 Aliskiren metabolite M2 Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
References
1 Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.

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