Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000133)
Formula
SVG example
O-Dealkylation
Reactant Aliskiren Product Aliskiren metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000134 Aliskiren Aliskiren metabolite M1 Oxidation - O-Demethylation Aliskiren [1]
MR000136 Aliskiren Aliskiren metabolite M12 Unclear Aliskiren [2]
MR000132 Aliskiren Aliskiren metabolite M3 Oxidation - O-Demethylation Aliskiren [1]
MR000135 Aliskiren Aliskiren metabolite M9 Hydrolysis - Hydrolysis Aliskiren [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000129 Aliskiren metabolite M3 Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
MR000130 Aliskiren metabolite M2 Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000131 Aliskiren metabolite M4 Aliskiren metabolite M6 Conjugation - O-Glucuronidation Aliskiren [1]
References
1 Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.
2 U. S. FDA Label - Aliskiren

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.