Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000130)
Formula
SVG example
O-Dealkylation
Reactant Aliskiren metabolite M2 Product Aliskiren metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000128 Aliskiren metabolite M3 Aliskiren metabolite M2 Oxidation - Oxidation Aliskiren [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000133 Aliskiren Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
MR000129 Aliskiren metabolite M3 Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000131 Aliskiren metabolite M4 Aliskiren metabolite M6 Conjugation - O-Glucuronidation Aliskiren [1]
References
1 Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.

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