General Information of This Metabolic Reaction (MR) (ID: MR000135)
Formula
SVG example
Hydrolysis
Reactant Aliskiren Product Aliskiren metabolite M9
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000134 Aliskiren Aliskiren metabolite M1 Oxidation - O-Demethylation Aliskiren [1]
MR000136 Aliskiren Aliskiren metabolite M12 Unclear Aliskiren [2]
MR000132 Aliskiren Aliskiren metabolite M3 Oxidation - O-Demethylation Aliskiren [1]
MR000133 Aliskiren Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [1]
References
1 Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.
2 U. S. FDA Label - Aliskiren

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