Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR000135)
Formula	Hydrolysis
	Reactant	Aliskiren		Product	Aliskiren metabolite M9
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR000134	Aliskiren	Aliskiren metabolite M1	Oxidation - O-Demethylation	Aliskiren	[1]
MR000136	Aliskiren	Aliskiren metabolite M12	Unclear	Aliskiren	[2]
MR000132	Aliskiren	Aliskiren metabolite M3	Oxidation - O-Demethylation	Aliskiren	[1]
MR000133	Aliskiren	Aliskiren metabolite M4	Oxidation - O-Dealkylation	Aliskiren	[1]

References
1	Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.
2	U. S. FDA Label - Aliskiren

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