Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000134)
Formula
SVG example
O-Demethylation
Reactant Aliskiren Product Aliskiren metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000136 Aliskiren Aliskiren metabolite M12 Unclear Aliskiren [1]
MR000132 Aliskiren Aliskiren metabolite M3 Oxidation - O-Demethylation Aliskiren [2]
MR000133 Aliskiren Aliskiren metabolite M4 Oxidation - O-Dealkylation Aliskiren [2]
MR000135 Aliskiren Aliskiren metabolite M9 Hydrolysis - Hydrolysis Aliskiren [1]
References
1 U. S. FDA Label - Aliskiren
2 Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers Drug Metab Dispos. 2007 Aug;35(8):1418-28. doi: 10.1124/dmd.106.013797.

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