Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000181)
Formula Reactant Amlodipine besylate Product Amlodipine besylate metabolite M9
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000182 Amlodipine besylate Amlodipine besylate metabolite M3 Oxidation - Monohydroxylation Amlodipine besylate [1]
MR000195 Amlodipine besylate Amlodipine besylate metabolite M3 Oxidation - Monohydroxylation Amlodipine maleate [1]
MR000183 Amlodipine besylate Amlodipine besylate metabolite M5 Oxidation - Monohydroxylation Amlodipine besylate [1]
MR000196 Amlodipine besylate Amlodipine besylate metabolite M5 Oxidation - Monohydroxylation Amlodipine maleate [1]
MR000184 Amlodipine besylate Amlodipine besylate metabolite M6 Oxidation - O-Demethylation Amlodipine besylate [1]
MR000197 Amlodipine besylate Amlodipine besylate metabolite M6 Oxidation - O-Demethylation Amlodipine maleate [1]
MR000185 Amlodipine besylate Amlodipine besylate metabolite M8 Oxidation - Monohydroxylation Amlodipine besylate [1]
MR000198 Amlodipine besylate Amlodipine besylate metabolite M8 Oxidation - Monohydroxylation Amlodipine maleate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000176 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite H Unclear Amlodipine besylate [2]
MR000189 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite H Unclear Amlodipine maleate [2]
MR000174 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M1 Oxidation - O-Demethylation Amlodipine besylate [1]
MR000187 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M1 Oxidation - O-Demethylation Amlodipine maleate [1]
MR000173 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M10 Oxidation - Oxidative Deamination Amlodipine besylate [1]
MR000186 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M10 Oxidation - Oxidative Deamination Amlodipine maleate [1]
MR000175 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M4 Oxidation - O-Dealkylation Amlodipine besylate [1]
MR000188 Amlodipine besylate metabolite M9 Amlodipine besylate metabolite M4 Oxidation - O-Dealkylation Amlodipine maleate [1]
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References
1 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.
2 Metabolism and kinetics of amlodipine in man Xenobiotica. 1988 Feb;18(2):245-54. doi: 10.3109/00498258809041660.

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