Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000198)
Formula Reactant Amlodipine besylate Product Amlodipine besylate metabolite M8
Reactant Info Product Info
Metabolic Type Oxidation - Monohydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000182 Amlodipine besylate Amlodipine besylate metabolite M3 Oxidation - Monohydroxylation Amlodipine besylate [1]
MR000195 Amlodipine besylate Amlodipine besylate metabolite M3 Oxidation - Monohydroxylation Amlodipine maleate [1]
MR000183 Amlodipine besylate Amlodipine besylate metabolite M5 Oxidation - Monohydroxylation Amlodipine besylate [1]
MR000196 Amlodipine besylate Amlodipine besylate metabolite M5 Oxidation - Monohydroxylation Amlodipine maleate [1]
MR000184 Amlodipine besylate Amlodipine besylate metabolite M6 Oxidation - O-Demethylation Amlodipine besylate [1]
MR000197 Amlodipine besylate Amlodipine besylate metabolite M6 Oxidation - O-Demethylation Amlodipine maleate [1]
MR000181 Amlodipine besylate Amlodipine besylate metabolite M9 Oxidation - Dehydrogenation Amlodipine besylate [1]
MR000194 Amlodipine besylate Amlodipine besylate metabolite M9 Oxidation - Dehydrogenation Amlodipine maleate [1]
References
1 Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9.

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