Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000206)
Formula
SVG example
Hydroxylation
Reactant Amoxapine Product 8-hydroxyamoxapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000205 Amoxapine 7-hydroxyamoxapine Oxidation - Hydroxylation Amoxapine [1], [2]
MR000207 Amoxapine N-Formyl-7-hydroxyamoxapine Unclear Amoxapine [3]
MR000208 Amoxapine N-Formylamoxapine Unclear Amoxapine [3]
References
1 Addition of amoxapine improves positive and negative symptoms in a patient with schizophrenia. Ther Adv Psychopharmacol. 2013 Dec;3(6):340-2.
2 DrugBank(Pharmacology-Metabolism)Amoxapine
3 Transformation of amoxapine by Cunninghamella elegans Appl Environ Microbiol. 2000 Aug;66(8):3646-9. doi: 10.1128/AEM.66.8.3646-3649.2000.

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