Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000228)
Formula Reactant Amprenavir Product Amprenavir metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000227 Amprenavir Amprenavir metabolite M1 Unclear Amprenavir [1]
MR000229 Amprenavir Amprenavir metabolite M3 Unclear Amprenavir [1]
MR000230 Amprenavir Amprenavir metabolite M4 Unclear Amprenavir [1]
MR000231 Amprenavir Amprenavir metabolite M5 Unclear Amprenavir [1]
MR002852 Amprenavir GW549444 Unclear Fosamprenavir [2]
MR002853 Amprenavir GW549445 Unclear Fosamprenavir [2]
References
1 Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation. Drug Metab Dispos. 2003 Mar;31(3):275-81.
2 Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68.

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