Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002852)
Formula
SVG example
Reactant Amprenavir Product GW549444
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000227 Amprenavir Amprenavir metabolite M1 Unclear Amprenavir [1]
MR000228 Amprenavir Amprenavir metabolite M2 Unclear Amprenavir [1]
MR000229 Amprenavir Amprenavir metabolite M3 Unclear Amprenavir [1]
MR000230 Amprenavir Amprenavir metabolite M4 Unclear Amprenavir [1]
MR000231 Amprenavir Amprenavir metabolite M5 Unclear Amprenavir [1]
MR002853 Amprenavir GW549445 Unclear Fosamprenavir [2]
References
1 Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation. Drug Metab Dispos. 2003 Mar;31(3):275-81.
2 Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68.

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