Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000237)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Anastrozole Product Hydroxyanastrozole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000240 Anastrozole 3,5-Bis-(2-methylpropiononitrile)-benzoic acid Oxidation - N-Dealkylation Anastrozole [1]
MR000238 Anastrozole Anastrozole glucuronide metabolite Unclear Anastrozole [2], [3]
MR000239 Anastrozole Triazole Oxidation - N-Dealkylation Anastrozole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000236 Hydroxyanastrozole Hydroxyanastrozole glucuronide metabolite Conjugation - O-Glucuronidation Anastrozole [4]
References
1 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.
2 Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation. Drug Metab Dispos. 2003 Mar;31(3):275-81.
3 Anastrozole and related glucuronic acid conjugate are electrophilic species. Xenobiotica. 2022 Apr;52(4):380-388. doi: 10.1080/00498254.2022.2086503.
4 DrugBank(Pharmacology-Metabolism)Anastrozole

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