Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000381)
Formula
CYP3A4 ...
SVG example
Reactant BMS-298585 Product BMS-298585 metabolite M10
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000376 BMS-298585 BMS-298585 metabolite M1 Oxidation - O-Dealkylation BMS-298585 [1], [2]
MR000382 BMS-298585 BMS-298585 metabolite M11 Unclear BMS-298585 [1], [2]
MR000383 BMS-298585 BMS-298585 metabolite M13 Unclear BMS-298585 [1], [2]
MR000380 BMS-298585 BMS-298585 metabolite M14 Unclear BMS-298585 [1], [2]
MR000379 BMS-298585 BMS-298585 metabolite M15 Unclear BMS-298585 [1], [2]
MR000378 BMS-298585 BMS-298585 metabolite M16 Unclear BMS-298585 [1], [2]
MR000377 BMS-298585 BMS-298585 metabolite M9 Unclear BMS-298585 [1], [2]
References
1 Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49.
2 Glucuronidation as a major metabolic clearance pathway of 14c-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection Drug Metab Dispos. 2006 Mar;34(3):427-39. doi: 10.1124/dmd.105.007617.

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