Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000376)
Formula
CYP3A4 ...
SVG example
O-Dealkylation
Reactant BMS-298585 Product BMS-298585 metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000381 BMS-298585 BMS-298585 metabolite M10 Unclear BMS-298585 [1], [2]
MR000382 BMS-298585 BMS-298585 metabolite M11 Unclear BMS-298585 [1], [2]
MR000383 BMS-298585 BMS-298585 metabolite M13 Unclear BMS-298585 [1], [2]
MR000380 BMS-298585 BMS-298585 metabolite M14 Unclear BMS-298585 [1], [2]
MR000379 BMS-298585 BMS-298585 metabolite M15 Unclear BMS-298585 [1], [2]
MR000378 BMS-298585 BMS-298585 metabolite M16 Unclear BMS-298585 [1], [2]
MR000377 BMS-298585 BMS-298585 metabolite M9 Unclear BMS-298585 [1], [2]
References
1 Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49.
2 Glucuronidation as a major metabolic clearance pathway of 14c-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection Drug Metab Dispos. 2006 Mar;34(3):427-39. doi: 10.1124/dmd.105.007617.

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