Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000464)
Formula Reactant Bromperidol Product Bromperidol to bromperidol 1,2,3,6-tetrahydropyridine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Other reaction - Dehydration
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000466 Bromperidol 4-fluorobenzoyl-propionic acid (FBPA) Unclear Bromperidol [1]
MR000465 Bromperidol Bromperidol pyridinium Unclear Bromperidol [2]
MR000463 Bromperidol Reduced bromperidol Oxidation - N-Dealkylation Bromperidol [2]
References
1 Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo Xenobiotica. 1999 Aug;29(8):839-46. doi: 10.1080/004982599238281.
2 Involvement of CYP3A4 in the metabolism of bromperidol in vitro. Pharmacol Toxicol. 2000 Mar;86(3):145-8.

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