Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000465)
Formula Reactant Bromperidol Product Bromperidol pyridinium
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A43 (CYP3A43) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000466 Bromperidol 4-fluorobenzoyl-propionic acid (FBPA) Unclear Bromperidol [1]
MR000464 Bromperidol Bromperidol to bromperidol 1,2,3,6-tetrahydropyridine Other reaction - Dehydration Bromperidol [2]
MR000463 Bromperidol Reduced bromperidol Oxidation - N-Dealkylation Bromperidol [2]
References
1 Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo Xenobiotica. 1999 Aug;29(8):839-46. doi: 10.1080/004982599238281.
2 Involvement of CYP3A4 in the metabolism of bromperidol in vitro. Pharmacol Toxicol. 2000 Mar;86(3):145-8.

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