Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000539)
Formula
XDH
SVG example
Oxidation
Reactant 1-Methylxanthine Product 1-Methyluric acid
Reactant Info Product Info
Metabolic Enzyme Xanthine dehydrogenase/oxidase (XDH) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004944 Theophylline 1-Methylxanthine Oxidation - 3-N-demethylation Theophylline [1]
MR000540 Paraxanthine 1-Methylxanthine Oxidation - 7-N-Demethylation Caffeine [2], [3]
MR000547 Theophylline 1-Methylxanthine Oxidation - 3-N-Demethylation Caffeine [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001873 Oxtriphylline 1-Methyluric acid Unclear Oxtriphylline [4]
References
1 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.
2 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.
3 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
4 Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma Clin Pharmacol Ther. 2003 May;73(5):468-74. doi: 10.1016/s0009-9236(03)00013-4.

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