Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000540)
Formula
XDH
SVG example
7-N-Demethylation
Reactant Paraxanthine Product 1-Methylxanthine
Reactant Info Product Info
Metabolic Enzyme Xanthine dehydrogenase/oxidase (XDH) DME Info
Metabolic Type Oxidation - 7-N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000543 Caffeine Paraxanthine Oxidation - Demethylation Caffeine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000541 Paraxanthine 1,7-Dimethyluric acid Oxidation - 3-N-Demethylation Caffeine [3], [2]
MR000542 Paraxanthine 5-Acetylamino-6-formylamino-3-methyluracil Unclear Caffeine [4], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004944 Theophylline 1-Methylxanthine Oxidation - 3-N-demethylation Theophylline [5]
MR000547 Theophylline 1-Methylxanthine Oxidation - 3-N-Demethylation Caffeine [4], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004945 1-Methylxanthine 1-methyluric acid Oxidation - Hydrolyzationn Theophylline [5]
MR000539 1-Methylxanthine 1-Methyluric acid Oxidation - Oxidation Caffeine [4], [2]
References
1 Pharmacokinetic analysis and comparison of caffeine administered rapidly or slowly in coffee chilled or hot versus chilled energy drink in healthy young adults Clin Toxicol (Phila). 2016;54(4):308-12. doi: 10.3109/15563650.2016.1146740.
2 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
3 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.
4 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.
5 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.

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