Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001873)
Formula
SVG example
Reactant Oxtriphylline Product 1-Methyluric acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001874 Oxtriphylline 1,3-Dimethyluric acid Unclear Oxtriphylline [1]
MR001875 Oxtriphylline 3-Methylxanthine Unclear Oxtriphylline [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004945 1-Methylxanthine 1-methyluric acid Oxidation - Hydrolyzationn Theophylline [2]
MR000539 1-Methylxanthine 1-Methyluric acid Oxidation - Oxidation Caffeine [3], [4]
References
1 Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma Clin Pharmacol Ther. 2003 May;73(5):468-74. doi: 10.1016/s0009-9236(03)00013-4.
2 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.
3 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.
4 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.

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