Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000543)
Formula
SVG example
Demethylation
Reactant Caffeine Product Paraxanthine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000544 Caffeine 1,3,7-Trimethyluric acid Oxidation - 8-Hydroxylation Caffeine [1], [2]
MR000545 Caffeine Theobromine Oxidation - 1-N-Demethylation Caffeine [1], [2]
MR000546 Caffeine Theophylline Oxidation - 7-N-Demethylation Caffeine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000541 Paraxanthine 1,7-Dimethyluric acid Oxidation - 3-N-Demethylation Caffeine [1], [2]
MR000540 Paraxanthine 1-Methylxanthine Oxidation - 7-N-Demethylation Caffeine [3], [2]
MR000542 Paraxanthine 5-Acetylamino-6-formylamino-3-methyluracil Unclear Caffeine [3], [2]
References
1 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.
2 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
3 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.

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