Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000574)
Formula
UGT1A1 ...
SVG example
O-Glucuronidation
Reactant Carvedilol Product Carvedilol glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000573 Carvedilol 1-hydroxyphenylcarvedilol Oxidation - 1-Hydroxylation Carvedilol [1]
MR000570 Carvedilol 4'-hydroxyphenylcarvedilol Oxidation - 4'-Hydroxylation Carvedilol [1]
MR000571 Carvedilol 5'-hydroxyphenylcarvedilol Oxidation - 5'-Hydroxylation Carvedilol [1]
MR000569 Carvedilol 8-hydroxycarbazolylcarvedilol Oxidation - 8-Hydroxylation Carvedilol [1]
MR000572 Carvedilol O-Desmethylcarvedilol Oxidation - O-Demethylation Carvedilol [1]
References
1 Metabolism of carvedilol in dogs, rats, and mice Drug Metab Dispos. 1998 Oct;26(10):958-69.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.