Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000569)
Formula
CYP1A1 ...
SVG example
8-Hydroxylation
Reactant Carvedilol Product 8-hydroxycarbazolylcarvedilol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - 8-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000573 Carvedilol 1-hydroxyphenylcarvedilol Oxidation - 1-Hydroxylation Carvedilol [1]
MR000570 Carvedilol 4'-hydroxyphenylcarvedilol Oxidation - 4'-Hydroxylation Carvedilol [1]
MR000571 Carvedilol 5'-hydroxyphenylcarvedilol Oxidation - 5'-Hydroxylation Carvedilol [1]
MR000574 Carvedilol Carvedilol glucuronide Conjugation - O-Glucuronidation Carvedilol [1]
MR000572 Carvedilol O-Desmethylcarvedilol Oxidation - O-Demethylation Carvedilol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000564 8-hydroxycarbazolylcarvedilol Carvedilol metabolite M17 Conjugation - Glucuronidation Carvedilol [1]
References
1 Metabolism of carvedilol in dogs, rats, and mice Drug Metab Dispos. 1998 Oct;26(10):958-69.

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