Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000572)
Formula
CYP2C9 ...
SVG example
O-Demethylation
Reactant Carvedilol Product O-Desmethylcarvedilol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000573 Carvedilol 1-hydroxyphenylcarvedilol Oxidation - 1-Hydroxylation Carvedilol [1]
MR000570 Carvedilol 4'-hydroxyphenylcarvedilol Oxidation - 4'-Hydroxylation Carvedilol [1]
MR000571 Carvedilol 5'-hydroxyphenylcarvedilol Oxidation - 5'-Hydroxylation Carvedilol [1]
MR000569 Carvedilol 8-hydroxycarbazolylcarvedilol Oxidation - 8-Hydroxylation Carvedilol [1]
MR000574 Carvedilol Carvedilol glucuronide Conjugation - O-Glucuronidation Carvedilol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000567 O-Desmethylcarvedilol Carvedilol metabolite M3a/b Conjugation - Glucuronidation Carvedilol [1]
References
1 Metabolism of carvedilol in dogs, rats, and mice Drug Metab Dispos. 1998 Oct;26(10):958-69.

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