Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000602)
Formula
CYP3A4 ...
SVG example
Demethylation
Reactant Cerivastatin sodium Product Desmethylcerivastatin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000601 Cerivastatin sodium Hydroxycerivastatin Oxidation - Hydroxylation Cerivastatin sodium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000624 Chloramphenicol Desmethylcerivastatin Unclear Chloramphenicol [2]
References
1 DrugBank(Pharmacology-Metabolism)Cerivastatin
2 Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. Antimicrob Agents Chemother. 2003 Nov;47(11):3464-9.

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