Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000628)
Formula
CYP3A4 ...
SVG example
N-Dealkylation
Reactant Chloroquine Product (R)-chloroquine, N-desethyl
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000626 (R)-chloroquine, N-desethyl N-bidesethylchloroquine Oxidation - N-Dealkylation Chloroquine [1]
References
1 Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements Clin Pharmacokinet. 1996 Oct;31(4):257-74. doi: 10.2165/00003088-199631040-00003.

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