Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000733)
Formula
CYP3A4 ...
SVG example
N-Hydroxylation
Reactant Dapsone Product Dapsone hydroxylamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Myeloperoxidase (MPO) DME Info
Cytochrome c oxidase subunit 2 (MT-CO2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000734 Dapsone Monoacetyldapsone Unclear Dapsone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000730 Dapsone hydroxylamine Nitroso-dapsone Oxidation - Oxidation Dapsone [2]
References
1 High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population Clin Sci (Lond). 2009 Oct 26;118(3):187-94. doi: 10.1042/CS20090142.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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