Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000794)
Formula
SVG example
Oxidation
Reactant Dexlansoprazole Product Lansoprazole Sulfone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000796 Dexlansoprazole 4-sulfonyloxy dexlansoprazole Conjugation - Sulfation Dexlansoprazole [1]
MR000795 Dexlansoprazole 5-hydroxy dexlansoprazole Oxidation - 5-Hydroxylation Dexlansoprazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001414 Lansoprazole Lansoprazole sulfone Oxidation - Sulfoxidation Lansoprazole [2]
References
1 Absorption, distribution, metabolism and excretion of [14C]dexlansoprazole in healthy male subjects. Clin Drug Investig. 2012 May 1;32(5):319-32.
2 Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther. 1996 May;277(2):805-16.

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