Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000483)
DM Name	O-conjugate of temazepam

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Cytochrome P450 2B6 (CYP2B6)	DME0020	Temazepam metabolite M1	Oxidation - Demethylation	Temazepam	[1] , [2]
Cytochrome P450 2C8 (CYP2C8)	DME0018	Temazepam metabolite M1	Oxidation - Demethylation	Temazepam	[1] , [2]
Cytochrome P450 2C9 (CYP2C9)	DME0019	Temazepam metabolite M1	Oxidation - Demethylation	Temazepam	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Temazepam metabolite M1	Oxidation - Demethylation	Temazepam	[1] , [2]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Temazepam metabolite M1	Oxidation - Demethylation	Temazepam	[1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Temazepam metabolite M1	Oxidation - Demethylation	Temazepam	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Temazepam		DR1547	Approved		Insomnia

References
1	Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
2	Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J. 1999 Jun 15;340 ( Pt 3):845-53.

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