Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000483)
DM Name
O-conjugate of temazepam
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2B6 (CYP2B6) DME0020
Temazepam metabolite M1
Oxidation - Demethylation Temazepam [1] , [2]
Cytochrome P450 2C8 (CYP2C8) DME0018
Temazepam metabolite M1
Oxidation - Demethylation Temazepam [1] , [2]
Cytochrome P450 2C9 (CYP2C9) DME0019
Temazepam metabolite M1
Oxidation - Demethylation Temazepam [1] , [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
Temazepam metabolite M1
Oxidation - Demethylation Temazepam [1] , [2]
Cytochrome P450 3A5 (CYP3A5) DME0012
Temazepam metabolite M1
Oxidation - Demethylation Temazepam [1] , [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021
Temazepam metabolite M1
Oxidation - Demethylation Temazepam [1] , [2]
Full List of Drug(s) That Produce This DM By Metabolism
Temazepam DR1547 Approved Insomnia
References
1 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
2 Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J. 1999 Jun 15;340 ( Pt 3):845-53.

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