Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000825)
Formula
CYP2C19 ...
SVG example
Reactant Nordazepam Product Oxazepam
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002110 Nordazepam 4'-hydroxdesalkylprazepam Oxidation - Hydroxylation Prazepam [1], [2]
MR000824 Nordazepam Nordiazepam O-glucuronide Conjugation - O-Glucuronidation Diazepam [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011244 Chlordiazepoxide Oxazepam Unclear - Unclear Chlordiazepoxide [4]
MR005297 Clorazepic acid Oxazepam Unclear Clorazepic acid [5]
MR000820 Diazepam Oxazepam Oxidation - N-Demethylation Diazepam [6], [7], [8]
MR002378 Temazepam Oxazepam Oxidation - Demethylation Temazepam [9], [10]
MR011028 3-hydroxy-hazaepam Oxazepam Unclear - Unclear Halazepam [11]
MR002104 3-hydroxyprazepam Oxazepam Oxidation - N-Dealkylation Prazepam [1], [2]
MR011026 Desmethyl-diazepam Oxazepam Unclear - Unclear Halazepam [11]
MR000823 Temazepam Oxazepam Oxidation - N-Demethylation Diazepam [6], [8]
MR005846 Medazepam metabolite Oxazepam Unclear Medazepam [12], [13]
MR001326 Temazepam Oxazepam Oxidation - Demethylation Ketazolam [14]
MR005841 Medazepam metabolite Oxazepam Unclear Medazepam [12], [15]
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References
1 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
2 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
3 Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People Eur J Drug Metab Pharmacokinet. 2020 Aug;45(4):477-485. doi: 10.1007/s13318-020-00614-8.
4 Biological half-life of chlordiazepoxide and its metabolite, demoxepam, in man
5 Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography
6 DrugBank(Pharmacology-Metabolism)Diazepam
7 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
8 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
9 Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66.
10 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
11 Pharmacokinetics and metabolism of halazepam in naive and dependent dogs
12 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
13 Plasma concentrations of medazepam and its metabolites after oral administration
14 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
15 Further studies on medazepam metabolism in the rat

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