Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011026)
Formula Reactant Desmethyl-diazepam Product Oxazepam
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011243 Chlordiazepoxide Desmethyldiazepam Unclear - Unclear Chlordiazepoxide [1]
MR005298 Clorazepic acid Nordazepam Oxidation - N-demethylation Clorazepic acid [2]
MR000819 Diazepam Desmethyldiazepam Unclear Diazepam [3], [4]
MR011025 Halazepam Desmethyl-diazepam Unclear - Unclear Halazepam [5]
MR002107 Prazepam Nordazepam Oxidation - N-Dealkylation Prazepam [6], [7], [8]
MR001328 Diazepam Nordazepam Unclear Ketazolam [9], [4]
MR005847 Diazepam Medazepam metabolite Oxidation - N-demethylation Medazepam [10], [11]
MR005840 Medazepam metabolite Medazepam metabolite Unclear Medazepam [10], [12]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011244 Chlordiazepoxide Oxazepam Unclear - Unclear Chlordiazepoxide [13]
MR005297 Clorazepic acid Oxazepam Unclear Clorazepic acid [2]
MR000820 Diazepam Oxazepam Oxidation - N-Demethylation Diazepam [3], [4], [14]
MR004426 Nordazepam Oxazepam Oxidation - C3-hydroxylation Nordazepam [15], [16]
MR002378 Temazepam Oxazepam Oxidation - Demethylation Temazepam [17], [18]
MR011028 3-hydroxy-hazaepam Oxazepam Unclear - Unclear Halazepam [5]
MR002104 3-hydroxyprazepam Oxazepam Oxidation - N-Dealkylation Prazepam [7], [8]
MR000825 Nordazepam Oxazepam Unclear Diazepam [19], [4], [14]
MR002111 Nordazepam Oxazepam Oxidation - Hydroxylation Prazepam [6], [7], [8]
MR000823 Temazepam Oxazepam Oxidation - N-Demethylation Diazepam [3], [14]
MR005846 Medazepam metabolite Oxazepam Unclear Medazepam [10], [11]
MR001327 Nordazepam Oxazepam Oxidation - Hydroxylation Ketazolam [9]
MR001326 Temazepam Oxazepam Oxidation - Demethylation Ketazolam [9]
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References
1 Postmortem Brain and Blood Reference Concentrations of Alprazolam, Bromazepam, Chlordiazepoxide, Diazepam, and their Metabolites and a Review of the Literature
2 Determination of clorazepate and its major metabolites in blood and urine by electron capture gas-liquid chromatography
3 DrugBank(Pharmacology-Metabolism)Diazepam
4 Pharmacokinetics of Diazepam and Its Metabolites in Urine of Chinese Participants. Drugs R D. 2022 Mar;22(1):43-50. doi: 10.1007/s40268-021-00375-y.
5 Pharmacokinetics and metabolism of halazepam in naive and dependent dogs
6 Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463.
7 Prazepam metabolism by man Clin Pharmacol Ther. 1970 Nov-Dec;11(6):890-7. doi: 10.1002/cpt1970116890.
8 Prazepam metabolites in dog urine J Pharm Sci. 1970 Mar;59(3):322-5. doi: 10.1002/jps.2600590309.
9 Urinary diazepam metabolite distribution in a chronic pain population J Anal Toxicol. 2014 Apr;38(3):135-42. doi: 10.1093/jat/bku001.
10 Metabolism of 14C-medazepam hydrochloride in dog, rat and man
11 Plasma concentrations of medazepam and its metabolites after oral administration
12 Further studies on medazepam metabolism in the rat
13 Biological half-life of chlordiazepoxide and its metabolite, demoxepam, in man
14 Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control. J Vet Pharmacol Ther. 2021 Sep;44(5):733-744. doi: 10.1111/jvp.12991.
15 Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver
16 Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver
17 Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66.
18 Pharmacokinetics and metabolism of temazepam in man and several animal species Br J Clin Pharmacol. 1979;8(1):23S-29S. doi: 10.1111/j.1365-2125.1979.tb00451.x.
19 Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People Eur J Drug Metab Pharmacokinet. 2020 Aug;45(4):477-485. doi: 10.1007/s13318-020-00614-8.

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