Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000864)
Formula Reactant N-monodesmethyl diltilazem Product N,O-didesmethyl diltiazem
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000868 Diltiazem hydrochloride N-monodesmethyl diltilazem Oxidation - N-Demethylation Diltiazem hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000863 N-monodesmethyl diltilazem Deacetyl N-monodesmethyl diltiazem Conjugation - Acetylation Diltiazem hydrochloride [2]
References
1 Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3.
2 Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796.

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