Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000868)
Formula Reactant Diltiazem hydrochloride Product N-monodesmethyl diltilazem
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000869 Diltiazem hydrochloride Deacetyl diltiazem Oxidation - Deacetylation Diltiazem hydrochloride [1]
MR000870 Diltiazem hydrochloride O-desmethyl diltiazem Oxidation - O-Demethylation Diltiazem hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000863 N-monodesmethyl diltilazem Deacetyl N-monodesmethyl diltiazem Conjugation - Acetylation Diltiazem hydrochloride [2]
MR000864 N-monodesmethyl diltilazem N,O-didesmethyl diltiazem Oxidation - O-Demethylation Diltiazem hydrochloride [2], [1]
References
1 Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3.
2 Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796.

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