Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000953)
Formula
SVG example
Reactant Esomeprazole Product Active metabolite of Esomeprazole
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000956 Esomeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Esomeprazole [1]
MR000955 Esomeprazole 5-O-Desmethylomeprazole Oxidation - O-Dealkylation Esomeprazole [2]
MR000954 Esomeprazole Omeprazole sulfone metabolite Oxidation - S-Oxidation Esomeprazole [3], [1]
References
1 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.
2 Expression, activity and regulation of CYP3A in human and rodent brain Drug Metab Rev. 2008;40(1):149-68. doi: 10.1080/03602530701836712.
3 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.

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